The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

Ischemia/reperfusion (I/R) injury is one of the main causes acute kidney injury. The pathological mechanisms underlying renal I/R are complex and remain uncertain. protective effects antioxidant properties geraniol against ischemia reperfusion damage were investigated in our study. 28 Wistar albino male rats randomly selected 4 groups n = 7 created. A right nephrectomy surgery was conducted to all under anesthesia. 2 ml SF given Groups I II, 50 mg/kg 100 mg/ kg administered intraperitoneally an hour before III IV, respectively. Except for Group I, 45 minutes hours applied groups. At end experiment, parameters related oxidative stress inflammation determined by comparing function, enzyme activities histological changes. Following comparison BUN CRE values with CAT SOD tissue samples increase II observed as a result formation occurred. Values geraniol-treated IV approximated that dose proved more effective than geraniol.